A review of the molecular mechanisms of hyperglycemia‐induced free radical generation leading to oxidative stress. Issue 2 (26th August 2018)

• Record Type: Journal Article
• Authors: Yaribeygi, Habib; Atkin, Stephen L.; Sahebkar, Amirhossein
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 2(2019:Feb.)
• Page Start: 1300
• Page End: 1312
• Publication Date: 2018-08-26
• Subjects: cytochrome P450 enzyme system -- diabetes complications -- free radicals -- hyperglycemia -- NADPH oxidase -- oxidative stress; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.27164
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: The prevalence of diabetes is growing worldwide with an increasing morbidity and mortality associated with the development of diabetes complications. Free radical production is a normal biological process that is strictly controlled and has been shown to be important in normal cellular homeostasis, and in the bodies response to pathogens. However, there are several mechanisms leading to excessive free radical production that overcome the normal protective quenching mechanisms. Studies have shown that many of the diabetes complications result from excessive free radical generation and oxidative stress, and it has been shown that chronic hyperglycemia is a potent inducer for free radical production, generated through several pathways and triggering multiple molecular mechanisms. An understanding of these processes may help us to improving our preventive or therapeutic strategies. In this review, the major molecular pathways involved in free radical generation induced by hyperglycemia are described. Abstract : Studies have shown that many of the diabetes complications result from excessive free radical generation and oxidative stress, and it has been shown that chronic hyperglycemia is a potent inducer for free radical production, generated through several pathways and triggering multiple molecular mechanisms. An understanding of these processes may help us to improving our preventive or therapeutic strategies. In this review, the major molecular pathways involved in free radical generation induced by hyperglycemia are described.