Intra-amniotic inflammatory complications in preterm prelabor rupture of membranes and long-term neurodevelopmental outcomes of infants: a systematic review. (12th December 2022)

• Record Type: Journal Article
• Authors: Burckova, Hana; Stranik, Jaroslav; Musilova, Ivana; Matulova, Jana; Jacobsson, Bo; Kacerovsky, Marian
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 35:Number 25(2022)
• Page Start: 5993
• Page End: 5998
• Publication Date: 2022-12-12
• Subjects: Amniocentesis -- intra-amniotic inflammation -- cerebral palsy -- cognitive -- microbial invasion of the amniotic cavity -- morbidity -- neurodevelopment -- preterm labor -- psycho-motoric; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2021.1903859
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective: To perform a systematic review of the literature available on the association between the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation and long-term neurodevelopmental outcomes of infants from pregnancies complicated by preterm prelabor rupture of membranes (PPROM). Methods: A literature search, from their earliest entries to May 2020, was performed by employing three electronic databases (Web of Science, PubMed, and Scopus). The selection criteria were as follows: (1) singleton pregnancies with PPROM; (2) available information regarding MIAC and/or intra-amniotic inflammation; (3) long-term (at least one year of the corrected age) neurodevelopmental outcomes of respective infants. Results: The initial search identified 10, 953 articles, of which 8 were selected for full-text reading; however, none were included in the review owing to the following reasons: (i) spontaneous preterm labor with intact membranes and/or indicated (iatrogenic) preterm delivery were included in the studies without providing separate data for PPROM ( n = 5); (ii) long-term, at least one year of the corrected age, neurodevelopmental outcomes of infants were not assessed ( n = 1); (iii) the presence of both the abovementioned reasons ( n = 1); (iv) amniotic fluid was not assessed, and a long-term neurodevelopmental outcome was not evaluated ( n = 1). Conclusion: The literature search provides evidence of a knowledge gap in the association between the presence of MIAC and/or intra-amniotic inflammation and long-term neurodevelopmental outcomes in infants with PPROM.