Cutaneous cytomegalovirus – A case of disseminated cytomegalovirus presenting with extensive ulcerative skin lesions in a renal transplant recipient. Issue 4 (16th February 2021)

• Record Type: Journal Article
• Authors: Ferguson, Jessica; Mooney, Kelly; Saleem, Atif; Stevens, Bryan A.; Pinsky, Benjamin A.; Centkowski, Sierra; Zaba, Lisa C.; Ho, Dora Y.
• Is Part Of: Transplant infectious disease. Volume 23:Issue 4(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-02-16
• Subjects: cutaneous cytomegalovirus -- disseminated cytomegalovirus -- renal transplant; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.13582
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: Cytomegalovirus (CMV) reactivation is common in organ transplant recipients and can lead to significant morbidity and mortality. Cutaneous CMV findings are rarely reported in the literature and diagnosis can be delayed if not clinically recognized. We describe a case of a female patient 20 years post renal transplant who presented with extensive ulcerative skin lesions and diarrhea. She rapidly deteriorated and died on day 5 of hospitalization. Autopsy noted extensive CMV involvement of skin and gastrointestinal (GI) tract by CMV‐specific immunohistochemistry. These findings, along with high‐grade CMV viremia, led to the final postmortem diagnosis of disseminated CMV infection. This case focuses on the cutaneous findings of disseminated CMV as recognition of CMV skin lesions can lead to earlier initiation of appropriate therapy in transplant recipients.