Chronic deciduitis in stillbirths: are there any specific clinical associations?. (12th December 2022)

• Record Type: Journal Article
• Authors: Avagliano, Laura; Monari, Francesca; Salerno, Cristina; Menichini, Daniela; Facchinetti, Fabio; Bulfamante, Gaetano
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 35:Number 25(2022)
• Page Start: 8233
• Page End: 8236
• Publication Date: 2022-12-12
• Subjects: Deciduitis -- stillbirth -- placenta -- autoimmunity; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2021.1967317
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Introduction: Placental chronic deciduitis is a lesion consistent with the presence of plasma cells within the placental basal plate. It could be associated with adverse pregnancy outcomes, including stillbirth. Methods: We retrospectively evaluated a cohort of 180 antepartum stillborn cases from singleton pregnancies, with the aim of investigating the clinical-histopathological relationship. Placental slides were reviewed following the standard protocol proposed by the "Amsterdam consensus statement". Results: We observed an association between chronic deciduitis and lesions consistent with maternal vascular malperfusion, delayed villous maturation, villitis of unknown etiology and maternal autoimmunity. Conclusions: The observed clinical-histopathological associations suggest that an extensive maternal investigation could improve the comprehension of factors interfering with the placental development and the increasing risk of adverse pregnancy outcomes. Highlights: Chronic deciduitis is associated with lesions consistent with maternal vascular malperfusion Chronic deciduitis is associated with delayed villous maturation Chronic deciduitis is associated with villitis of unknown etiology Chronic deciduitis is associated with maternal autoimmunity