Use of convalescent plasma in COVID‐19 patients with immunosuppression. Issue 8 (1st June 2021)
- Record Type:
- Journal Article
- Title:
- Use of convalescent plasma in COVID‐19 patients with immunosuppression. Issue 8 (1st June 2021)
- Main Title:
- Use of convalescent plasma in COVID‐19 patients with immunosuppression
- Authors:
- Senefeld, Jonathon W.
Klassen, Stephen A.
Ford, Shane K.
Senese, Katherine A.
Wiggins, Chad C.
Bostrom, Bruce C.
Thompson, Michael A.
Baker, Sarah E.
Nicholson, Wayne T.
Johnson, Patrick W.
Carter, Rickey E.
Henderson, Jeffrey P.
Hartman, William R.
Pirofski, Liise‐anne
Wright, R. Scott
Fairweather, De Lisa
Bruno, Katelyn A.
Paneth, Nigel S.
Casadevall, Arturo
Joyner, Michael J. - Abstract:
- Abstract: In the absence of effective countermeasures, human convalescent plasma has been widely used to treat severe acute respiratory syndrome coronavirus 2, the causative agent of novel coronavirus disease 19 (COVID‐19), including among patients with innate or acquired immunosuppression. However, the association between COVID‐19‐associated mortality in patients with immunosuppression and therapeutic use of convalescent plasma is unknown. We review 75 reports, including one large matched‐control registry study of 143 COVID‐19 patients with hematological malignancies, and 51 case reports and 23 case series representing 238 COVID‐19 patients with immunosuppression. We review clinical features and treatment protocols of COVID‐19 patients with immunosuppression after treatment with human convalescent plasma. We also discuss the time course and clinical features of recovery. The available data from case reports and case series provide evidence suggesting a mortality benefit and rapid clinical improvement in patients with several forms of immunosuppression following COVID‐19 convalescent plasma transfusion. The utility of convalescent plasma or other forms of antibody therapy in immune‐deficient and immune‐suppressed patients with COVID‐19 warrants further investigation.
- Is Part Of:
- Transfusion. Volume 61:Issue 8(2021)
- Journal:
- Transfusion
- Issue:
- Volume 61:Issue 8(2021)
- Issue Display:
- Volume 61, Issue 8 (2021)
- Year:
- 2021
- Volume:
- 61
- Issue:
- 8
- Issue Sort Value:
- 2021-0061-0008-0000
- Page Start:
- 2503
- Page End:
- 2511
- Publication Date:
- 2021-06-01
- Subjects:
- FFP transfusion -- transplantation—solid organ -- transfusion practices (oncology–hematology)
Hematology -- Periodicals
Blood -- Transfusion -- Periodicals
Blood Group Antigens -- Periodicals
Blood Preservation -- Periodicals
Blood Transfusion -- Periodicals
615 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1537-2995 ↗
http://www.blackwell-synergy.com/member/institutions/issuelist.asp?journal=trf ↗
http://www.transfusion.org ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/trf.16525 ↗
- Languages:
- English
- ISSNs:
- 0041-1132
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 9020.704000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 24397.xml