Blastomycosis in solid organ transplant recipients—A retrospective series from southeastern Wisconsin. Issue 4 (12th July 2021)

• Record Type: Journal Article
• Authors: Mehta, Tej I.; Kurman, Jonathan; Dolan, Stephen; Gill, Harpreet; Thapa, Bipin
• Is Part Of: Transplant infectious disease. Volume 23:Issue 4(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-07-12
• Subjects: blastomycosis -- fungal -- fungal infection -- invasive fungal infection -- transplant; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.13671
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: Blastomycosis is a fungal infection caused primarily by Blastomyces dermatitis . The fungus is endemic to the Ohio, Mississippi, and St. Lawrence River areas of the United States. Organ transplant recipients are at risk of blastomycosis due to pharmacologic immunosuppression. Over a 20‐year period, 30 cases of blastomycosis post‐solid organ transplantation were identified at our center. The cumulative incidence of blastomycosis among SOT recipients was 0.99%. There was a male predominance (70% male) and a median age of 59 at the time of diagnosis. Regarding transplant type, 23 patients received kidney transplants, 4 received liver transplants, 2 received pancreas transplants and 1 received a heart transplant. Median time to blastomycosis identification post‐transplant was 67.8 months (range: 1‐188 months). Amphotericin B was used as initiation therapy in most cases, followed by itraconazole, voriconazole, or in select cases fluconazole or posaconazole maintenance therapy. Regarding comorbid conditions, 87% of patients had diabetes, 50% had congestive heart failure, and 20% had chronic pulmonary disease. Nine patients (30%) developed blastomycosis‐related acute respiratory distress syndrome, 33% of these died with a median time to death of 22 days (range 20 days to 2 months); these were the only deaths attributable to blastomycosis.