Evaluation of the neutrophil‐to‐lymphocyte ratio, monocyte‐to‐lymphocyte ratio, and red cell distribution width for the prediction of prognosis of patients with hepatitis B virus‐related decompensated cirrhosis. Issue 11 (14th July 2020) - Li, XinKe
Abstract: Background: The development and progression of hepatitis B virus‐related decompensated cirrhosis (DeCi) is associated with inflammatory responses. The monocyte‐to‐lymphocyte ratio (MLR), neutrophil‐to‐lymphocyte ratio (NLR), and red cell distribution width (RDW) are well‐known inflammation markers. We aimed to assess the utility of these parameters for predicating the prognosis of patients with HBV‐DeCi. Methods: We retrospectively recruited 174 patients diagnosed with HBV‐DeCi. Univariate and multivariate regression models were used to determine risk factors for mortality. Areas under the receiver operating characteristic curves were calculated to estimate and compare the predictive values of the three parameters. Hepatic function was evaluated using the Model for End‐Stage Liver Disease (MELD) score. Results: The NLR, RDW, and MLR were found to be significantly higher in patients who did not survive compared with surviving patients. Moreover, these variables were all able to predict early poor outcomes in patients with HBV‐DeCi, with NLR exhibiting the highest accuracy. Furthermore, a combination of the NLR and MELD score was a more accurate prognostic marker for predicting mortality than either marker alone in such patients. Conclusions: Hematological parameters can provide prognostic information for patients with HBV‐DeCi. Routine assessment of these parameters at admission may provide valuable data to complement other conventional measures for assessing disease condition in patients with HBV‐DeCi. Abstract : Receiver operating characteristic curve analysis by neutrophil‐to‐lymphocyte ratio, red cell distribution width, monocyte‐to‐lymphocyte ratio, Model for End‐Stage Liver Disease score, and neutrophil‐to‐lymphocyte ratio combined with Model for End‐Stage Liver Disease score for predicting mortality in patients with hepatitis B virus‐related decompensated cirrhosis.