Delivery of therapeutics with nanoparticles: what's new in cancer immunotherapy?. (29th July 2016)

• Record Type: Journal Article
• Authors: Fontana, Flavia; Liu, Dongfei; Hirvonen, Jouni; Santos, Hélder A.
• Is Part Of: Wiley interdisciplinary reviews. Volume 9:Number 1(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-07-29
• Subjects: Nanomedicine -- Periodicals; Nanotechnology -- Periodicals; Biotechnology -- Periodicals; Ultrastructure (Biology) -- Periodicals; 610.28
• DOI: 10.1002/wnan.1421
• Languages: English
• ISSNs: 1939-5116

Abstract

Abstract : The application of nanotechnology to the treatment of cancer or other diseases has been boosted during the last decades due to the possibility to precise deliver drugs where needed, enabling a decrease in the drug's side effects. Nanocarriers are particularly valuable for potentiating the simultaneous co‐delivery of multiple drugs in the same particle for the treatment of heavily burdening diseases like cancer. Immunotherapy represents a new concept in the treatment of cancer and has shown outstanding results in patients treated with check‐point inhibitors. Thereby, researchers are applying nanotechnology to cancer immunotherapy toward the development of nanocarriers for delivery of cancer vaccines and chemo‐immunotherapies. Cancer nanovaccines can be envisioned as nanocarriers co‐delivering antigens and adjuvants, molecules often presenting different physicochemical properties, in cancer therapy. A wide range of nanocarriers (e.g., polymeric, lipid‐based and inorganic) allow the co‐formulation of these molecules, or the delivery of chemo‐ and immune‐therapeutics in the same system. Finally, there is a trend toward the use of biologically inspired and derived nanocarriers. In this review, we present the recent developments in the field of immunotherapy, describing the different systems proposed by categories: polymeric nanoparticles, lipid‐based nanosystems, metallic and inorganic nanosystems and, finally, biologically inspired and derived nanovaccines. WIREs Nanomed Nanobiotechnol 2017, 9:e1421. doi: 10.1002/wnan.1421 This article is categorized under: Biology-Inspired Nanomaterials > Lipid-Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Abstract :