Roles for SUMO in pre‐mRNA processing. (13th November 2015)

• Record Type: Journal Article
• Authors: Nuro‐Gyina, Patrick K.; Parvin, Jeffrey D.
• Is Part Of: Wiley interdisciplinary reviews. Volume 7:Number 1(2016:Jan./Feb.)
• Page Start: 105
• Page End: 112
• Publication Date: 2015-11-13
• Subjects: RNA -- Periodicals; 572.8805
• DOI: 10.1002/wrna.1318
• Languages: English
• ISSNs: 1757-7004

Abstract

Abstract : When the small ubiquitin‐like modifier (SUMO)‐1 protein is localized on the genome, it is found on proteins bound to the promoters of the most highly active genes and on proteins bound to the DNA‐encoding exons. Inhibition of the SUMO‐1 modification leads to reductions in initiation of messenger RNA (mRNA) synthesis and splicing. In this review, we discuss what is known about the SUMOylation of factors involved in transcription initiation, pre‐mRNA processing, and polyadenylation. We suggest a mechanism by which SUMO modifications of factors at the promoters of high‐activity genes trigger the formation of an RNA polymerase II complex that coordinates and integrates the stimulatory signals for each process to catalyze an extremely high level of gene expression. WIREs RNA 2016, 7:105–112. doi: 10.1002/wrna.1318 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications RNA Processing > Splicing Regulation/Alternative Splicing