Leukoaraiosis and acute ischemic stroke. (10th August 2021)

• Record Type: Journal Article
• Authors: Tang, Xiaojia; Jiang, Li; Luo, Yuhan; Fan, Hongyang; Song, Lilong; Liu, Peipei; Chen, Yingzhu
• Is Part Of: European journal of neuroscience. Volume 54:Number 6(2021)
• Page Start: 6202
• Page End: 6213
• Publication Date: 2021-08-10
• Subjects: ischemic stroke -- leukoaraiosis -- mechanism -- prognosis; Nervous system -- Periodicals; 612.8
• DOI: 10.1111/ejn.15406
• Languages: English
• ISSNs: 0953-816X

Abstract

Abstract: Ischaemic stroke is characterized by high morbidity, high disability rate, high mortality and high recurrence rate, which can have a grave impact on the quality of life of the patients and consequently becomes an economic burden on their families and society. With the developments in imaging technology in recent years, patients with acute cerebral infarction are predominantly more likely to be diagnosed with leukoaraiosis (LA). LA is a common degenerative disease of the nervous system, which is related to cognitive decline, depression, abnormal gait, ischaemic stroke and atherosclerosis. The aetiology of LA is not clear and there is no gold standard for imaging assessment. Related studies have shown that LA has an adverse effect on the prognosis of cerebral infarction, but some experts have contrary beliefs. Hence, we undertook the present review of the literature on the mechanism and the effect of LA on the prognosis of patients with acute ischaemic stroke. Abstract : Leukoaraiosis (LA) is a common degenerative disease of the nervous system, which is related to cognitive decline, depression, abnormal gait, ischaemic stroke and atherosclerosis. Interestingly, experts are divided on the effect of LA on the prognosis of patients with acute ischaemic stroke. Hereby, we undertook the present review of the literature on the mechanism and the effect of LA on the prognosis of patients with acute ischaemic stroke.