Oligodendrogenesis increases in hippocampal grey and white matter prior to locomotor or memory impairment in an adult mouse model of tauopathy. (14th April 2020)

• Record Type: Journal Article
• Authors: Ferreira, Solène; Pitman, Kimberley A.; Summers, Benjamin S.; Wang, Shiwei; Young, Kaylene M.; Cullen, Carlie L.
• Other Names: Majewska Ania guestEditor.; Verkhratsky Alexej guestEditor.; Hughes Ethan guestEditor.
• Is Part Of: European journal of neuroscience. Volume 54:Number 5(2021)
• Page Start: 5762
• Page End: 5784
• Publication Date: 2020-04-14
• Subjects: microtubule‐associated protein tau -- Myelin -- NG2‐glia -- oligodendrocyte progenitor cells -- tauopathy; Nervous system -- Periodicals; 612.8
• DOI: 10.1111/ejn.14726
• Languages: English
• ISSNs: 0953-816X

Abstract

Abstract: Myelin and axon losses are associated with cognitive decline in healthy ageing but are worse in people diagnosed with tauopathy. To determine whether tauopathy is also associated with enhanced myelin plasticity, we evaluated the behaviour of OPCs in mice that expressed a human pathological variant of microtubule‐associated protein tau ( MAPT P301S ). By 6 months of age (P180), MAPT P301S mice overexpressed hyperphosphorylated tau and had developed reactive gliosis in the hippocampus but had not developed overt locomotor or memory impairment. By performing cre‐lox lineage tracing of adult OPCs, we determined that the number of newborn oligodendrocytes added to the hippocampus, entorhinal cortex and fimbria was equivalent in control and MAPT P301S mice prior to P150. However, between P150 and P180, significantly more new oligodendrocytes were added to these regions in the MAPT P301S mouse brain. This large increase in new oligodendrocyte number was not the result of increased OPC proliferation, nor did it alter oligodendrocyte density in the hippocampus, entorhinal cortex or fimbria, which was equivalent in P180 wild‐type and MAPT P301S mice. Furthermore, the proportion of hippocampal and fimbria axons with myelin was unaffected by tauopathy. However, the proportion of myelinated axons that were ensheathed by immature myelin internodes was significantly increased in the hippocampus and fimbria of P180 MAPT P301S mice, when compared with their wild‐type littermates. These data suggest that MAPT P301S transgenic mice experience significant oligodendrocyte turnover, with newborn oligodendrocytes compensating for myelin loss early in the development of tauopathy. Abstract : Mice overexpressing a pathological variant of human microtubule‐associated protein tau ( MAPT P301S ) experience increased oligodendrogenesis in the hippocampus, entorhinal cortex and fimbria between 5 and 6 months of age. Total oligodendrocyte and oligodendrocyte progenitor cell number, axon density and the per cent of myelinated axons remain normal, though there is an increase in newly generated myelin, suggesting that oligodendrocyte turnover occurs early in the development of tauopathy.