High‐risk transcriptional profiles in multiple myeloma are an acquired feature that can occur in any subtype and more frequently with each subsequent relapse. (9th July 2021) - Boyle, Eileen M.; Rosenthal, Adam; Wang, Yan; Farmer, Philip; Rutherford, Michael; Ashby, Cody; Bauer, Michael; Johnson, Sarah K.; Wardell, Christopher P.; Hoering, Antje; Schinke, Carolina; Thanendrarajan, Sharmilan; et al.