Mathematical modeling of cardiac growth and remodeling. (7th March 2016)

• Record Type: Journal Article
• Authors: Lee, L.C.; Kassab, G.S.; Guccione, J.M.
• Is Part Of: Wiley interdisciplinary reviews. Volume 8:Number 3(2016)
• Page Start: 211
• Page End: 226
• Publication Date: 2016-03-07
• Subjects: Systems biology -- Periodicals; Medicine -- Periodicals; 610
• DOI: 10.1002/wsbm.1330
• Languages: English
• ISSNs: 1939-5094

Abstract

Abstract : This review provides an overview of the current state of mathematical models of cardiac growth and remodeling (G&R). We concisely describe the experimental observations associated with cardiac G&R and discuss existing mathematical models that describe this process. To facilitate the discussion, we have organized the G&R models in terms of (1) the physical focus (biochemical vs mechanical) and (2) the process that they describe (myocyte hypertrophy vs extracellular matrix remodeling). The review concludes with a discussion of some possible directions that can advance the existing state of cardiac G&R mathematical modeling. WIREs Syst Biol Med 2016, 8:211–226. doi: 10.1002/wsbm.1330 This article is categorized under: Analytical and Computational Methods > Computational Methods