Scarless wound healing: Transitioning from fetal research to regenerative healing. (9th January 2018)

• Record Type: Journal Article
• Authors: Moore, Alessandra L.; Marshall, Clement D.; Barnes, Leandra A.; Murphy, Matthew P.; Ransom, Ryan C.; Longaker, Michael T.
• Is Part Of: Wiley interdisciplinary reviews. Volume 7:Number 2(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-01-09
• Subjects: fetal wound healing -- fibrosis -- regenerative medicine -- scarless -- scarring -- wound healing; Developmental biology -- Periodicals; 571.805
• DOI: 10.1002/wdev.309
• Languages: English
• ISSNs: 1759-7684

Abstract

Abstract : Since the discovery of scarless fetal skin wound healing, research in the field has expanded significantly with the hopes of advancing the finding to adult human patients. There are several differences between fetal and adult skin that have been exploited to facilitate scarless healing in adults including growth factors, cytokines, and extracellular matrix substitutes. However, no one therapy, pathway, or cell subtype is sufficient to support scarless wound healing in adult skin. More recently, products that contain or mimic fetal and adult uninjured dermis were introduced to the wound healing market with promising clinical outcomes. Through our review of the major experimental targets of fetal wound healing, we hope to encourage research in areas that may have a significant clinical impact. Additionally, we will investigate therapies currently in clinical use and evaluate whether they represent a legitimate advance in regenerative medicine or a vulnerary agent. WIREs Dev Biol 2018, 7:e309. doi: 10.1002/wdev.309 This article is categorized under: Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration Plant Development > Cell Growth and Differentiation Adult Stem Cells, Tissue Renewal, and Regeneration > Environmental Control of Stem Cells Abstract : The discovery of fetal scarless skin wound healing is an important breakthrough whose investigation drives many aspects of regenerative medicine and stem cell research. Several features of fetal scarless wound healing are well studied, but the exact mechanism to recapitulate scarless wound healing in adult skin remains elusive (Reprinted with permission from Leavitt et al. (2016). Copyright 2016 Springer).