ALSUntangled #64: butyrates. Issue 7 (2nd October 2022)
- Record Type:
- Journal Article
- Title:
- ALSUntangled #64: butyrates. Issue 7 (2nd October 2022)
- Main Title:
- ALSUntangled #64: butyrates
- Authors:
- Sun, Yuyao
Bedlack, Richard
Armon, Carmel
Beauchamp, Morgan
Bertorini, Tulio
Bowser, Robert
Bromberg, Mark
Caress, James
Carter, Gregory
Crayle, Jesse
Cudkowicz, Merit E.
Glass, Jonathan D.
Jackson, Carlayne
Lund, Isaac
Martin, Sarah
Paganoni, Sabrina
Pattee, Gary
Ratner, Dylan
Salmon, Kristiana
Wicks, Paul - Abstract:
- Abstract: ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review butyrate and its different chemical forms (butyrates). Butyrates have plausible mechanisms for slowing ALS progression and positive pre-clinical studies. One trial suggests that sodium phenylbutyrate (NaPB) in combination with Tauroursodeoxycholic acid (TUDCA) can slow ALS progression and prolong survival, but the specific contribution of NaPB toward this effect is unclear. Butyrates appear reasonably safe for use in humans. Based on the above information, we support a trial of a butyrate in PALS, but we cannot yet recommend one as a treatment.
- Is Part Of:
- Amyotrophic lateral sclerosis and frontotemporal degeneration. Volume 23:Issue 7/8(2022)
- Journal:
- Amyotrophic lateral sclerosis and frontotemporal degeneration
- Issue:
- Volume 23:Issue 7/8(2022)
- Issue Display:
- Volume 23, Issue 7/8 (2022)
- Year:
- 2022
- Volume:
- 23
- Issue:
- 7/8
- Issue Sort Value:
- 2022-0023-NaN-0000
- Page Start:
- 638
- Page End:
- 643
- Publication Date:
- 2022-10-02
- Subjects:
- ALS -- butyrate -- gut microbiome -- neuroinflammation -- alternative therapy
616.839 - Journal URLs:
- http://informahealthcare.com/journal/afd ↗
http://informahealthcare.com ↗ - DOI:
- 10.1080/21678421.2022.2045323 ↗
- Languages:
- English
- ISSNs:
- 2167-8421
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0859.841188
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 24403.xml