The Efficiency of Glutamate Uptake Differs between Neonatal and Adult Cortical Microvascular Endothelial Cells. Issue 5 (May 2014)

• Record Type: Journal Article
• Authors: Lecointre, Maryline; Hauchecorne, Michelle; Chaussivert, Armelle; Marret, Stéphane; Leroux, Philippe; Jegou, Sylvie; Leroux-Nicollet, Isabelle; Gonzalez, Bruno J; Henry, Vincent J
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 34:Issue 5(2014)
• Page Start: 764
• Page End: 767
• Publication Date: 2014-05
• Subjects: brain development -- endothelium -- excitotoxicity -- glutamate -- immunohistochemistry; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1038/jcbfm.2014.30
• Languages: English
• ISSNs: 0271-678X

Abstract

Glutamate transporters (excitatory amino-acid transporters (EAATs)) are essential for brain homeostasis. While previous studies indicate that the vascular endothelium contributes to glutamate efflux in the adult brain, little information is available regarding glutamate uptake in the immature brain. The present study shows a differential expression pattern of EAATs between cortical microvessels in adults and newborns. In addition, adult cortical endothelial cells take up glutamate more efficiently than neonatal cells. Our findings indicate age-specific changes in extracellular glutamate regulation by brain endothelial cells, suggesting differences in the efficiency of glutamate efflux during an excitotoxic process that, in turn, may contribute to age-specific brain vulnerability.