Impact of Angiosome-Oriented Revascularization on Clinical Outcomes in Critical Limb Ischemia Patients Without Concurrent Wound Infection and Diabetes. (October 2014)

• Record Type: Journal Article
• Authors: Iida, Osamu; Takahara, Mitsuyoshi; Soga, Yoshimitsu; Yamauchi, Yasutaka; Hirano, Keisuke; Tazaki, Junichi; Yamaoka, Terutoshi; Suematsu, Nobuhiro; Suzuki, Kenji; Shintani, Yoshiaki; Miyashita, Yusuke; Uematsu, Masaaki
• Is Part Of: Journal of endovascular therapy. Volume 21:Number 5(2014)
• Page Start: 607
• Page End: 615
• Publication Date: 2014-10
• Subjects: endovascular therapy -- critical limb ischemia -- angiosome -- ulcer -- infection -- diabetes -- balloon angioplasty -- wound healing -- infrapopliteal arteries -- propensity matching analysis -- revascularization -- amputation -- reintervention; Blood-vessels -- Endoscopic surgery -- Periodicals; Angioscopy -- Periodicals; Intravenous catheterization -- Periodicals; Peripheral vascular diseases -- Treatment -- Periodicals; Vascular Surgical Procedures -- Periodicals; Angioscopy -- Periodicals; Catheterization, Peripheral -- Periodicals; Peripheral Vascular Diseases -- therapy -- Periodicals; Angioscopie; Maladies vasculaires périphériques; 617.413
• DOI: 10.1583/14-4692R.1
• Languages: English
• ISSNs: 1526-6028

Abstract

Purpose: To investigate the impact of angiosome-oriented revascularization on clinical outcomes in critical limb ischemia (CLI) patients excluding those with both diabetes and wound infection. Methods: Using a retrospective multicenter database, a propensity score matching analysis was performed of 539 consecutive CLI patients (375 men; mean age 71±11 years) without concurrent wound infection and diabetes who underwent balloon angioplasty of isolated infrapopliteal lesions. Propensity score matching produced 2 groups of 182 patients each who underwent angiosome-oriented direct revascularization (123 men; mean age 72±11 years) or indirect revascularization (125 men; mean age 72±11 years). The groups were compared for wound healing rate, freedom from major adverse limb events (MALE), and amputation-free survival (AFS). Results: In the overall population, indirect revascularization was performed in 36.6% (n=197). In the propensity matching analysis, the complete wound healing rate at 12 months was higher in the direct group than the indirect revascularization patients (75% vs. 64%, p=0.01), while freedom from MALE (p=0.99) and AFS (p=0.17) were not significantly different at up to 24 months. In multivariate analysis, indirect revascularization had an independent negative impact on wound healing (adjusted hazard ratio 0.7, p=0.008). Conclusion: After propensity matching analysis for CLI patients other than those with both diabetes and wound infection, the wound healing rate was higher after direct revascularization than after indirect revascularization, whereas MALE and AFS were not significantly different.