Congenital Langerhans Cell Histiocytosis with Placental Involvement. (May 2013)

• Record Type: Journal Article
• Authors: Terry, Jefferson; Pluchinotta, Francesca R.; Sanders, Stephen P.; Vergilio, Jo-Anne; Hyde, Scott R.; Boyd, Theonia K.
• Is Part Of: Pediatric and developmental pathology. Volume 16:Number 3(2013)
• Page Start: 224
• Page End: 228
• Publication Date: 2013-05
• Subjects: congenital -- Langerhans cell histiocytosis -- placenta; Pediatric pathology -- Periodicals; Children -- Diseases -- Periodicals; Diagnosis, Laboratory -- Periodicals; Abnormalities, Human -- Periodicals; Child development -- Periodicals; Pediatrics -- Periodicals; 616.07
• DOI: 10.2350/12-11-1277-CR.1
• Languages: English
• ISSNs: 1093-5266

Abstract

Congenital presentations of Langerhans cell histiocytosis (LCH) are exceedingly rare, and concurrent placental parenchymal involvement has not been definitively documented in the literature. We present 2 cases of congenital multisystem LCH with placental involvement resembling chronic villitis. Placental examination may provide the initial diagnostic evidence of LCH and may significantly influence patient management and outcome; however, the prognostic implications remain unclear. In a clinical context suspicious for congenital LCH, the observation of chronic villitis should prompt consideration of placental involvement by LCH.