Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke. (December 2022)

• Record Type: Journal Article
• Authors: Li, Xiang; Han, Zhihui; Wang, Tianyi; Ma, Cheng; Li, Haiying; Lei, Huali; Yang, Yuqi; Wang, Yuanjie; Pei, Zifan; Liu, Zhuang; Cheng, Liang; Chen, Gang
• Is Part Of: Biomaterials. Volume 291(2022)
• Publication Date: 2022-12
• Subjects: Ischemia-reperfusion injury -- Ceria nanoparticles -- Dl-3-n-butylphthalide -- ROS scavenge -- Mitochondrial protection; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2022.121904
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Oxidative stress and mitochondrial damage are the main mechanisms of ischemia-reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free radical scavenging ability were used as carriers to load dl-3- n -butylphthalide (NBP–CeO2 NPs) for the combined treatment of ischemic stroke. NBP-CeO2 NPs could eliminate reactive oxygen species (ROS) in mouse brain microvascular endothelial cells and hippocampal neurons after oxygen-glucose deprivation/reoxygenation (OGD/R), and also save mitochondrial membrane potential, morphology, and function, thus alleviating the in vitro blood brain barrier (BBB) disruption and neuronal apoptosis. In the middle cerebral artery embolization/recanalization (MCAO/R) mouse model, the NBP-CeO2 NPs also possessed superior ROS scavenging ability, protected mitochondria, and preserved BBB integrity, thereby reducing cerebral infarction and cerebral edema and inhibiting neuroinflammation and neuronal apoptosis. The long-term neurobehavioral tests indicated that the NBP-CeO2 NPs significantly improved sensorimotor function and spatial learning ability by promoting angiogenesis after ischemic stroke. Therefore, the NBP-CeO2 NPs provided a novel therapeutic approach for ischemic stroke by combining antioxidant and neurovascular repair abilities, highlighting its wide application in ischemia-reperfusion injury. Graphical abstract: Image 1