New Opportunities for the Utilization of the Sulfoximine Group in Medicinal Chemistry from the Drug Designer's Perspective. Issue 56 (3rd August 2022)

• Record Type: Journal Article
• Authors: Lücking, Ulrich
• Is Part Of: Chemistry. Volume 28:Issue 56(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-03
• Subjects: drug design -- innovation -- life sciences -- medicinal chemistry -- sulfoximines; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202201993
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Extension of the medicinal chemistry toolbox is in the vital interest of drug designers. However, the diffusion of an innovation can be a lengthy process. Along these lines, it took almost 70 years before the use of the sulfoximine group reached a critical mass in medicinal chemistry. Even though interest in this versatile functional group has increased exponentially in recent years, there is ample room for further innovative applications. This Review highlights emerging trends and opportunities for drug designers for the utilization of the sulfoximine group in medicinal chemistry, such as in the construction of complex molecules, proteolysis targeting chimeras (PROTACs), antibody‐drug conjugates (ADCs) and novel warheads for covalent inhibition. Abstract : The sulfoximine group has emerged from a 'lab oddity' to become a 'rising star in modern drug discovery'. Even though the increasing interest in this versatile functional group in recent years has resulted in several sulfoximine clinical candidates, there is ample room for further innovative applications. This minireview highlights emerging trends and opportunities for drug designers for the utilization of the sulfoximine group, such as in the construction of complex molecules, PROTACs, ADCs and novel warheads for covalent inhibition.