Ferroptosis in tumor immunity and therapy. Issue 22 (1st November 2022)

• Record Type: Journal Article
• Authors: Gong, Chuandong; Ji, Qiankun; Wu, Miaojing; Tu, Zewei; Lei, Kunjian; Luo, Min; Liu, Junzhe; Lin, Li; Li, Kuangxun; Li, Jingying; Huang, Kai; Zhu, Xingen
• Is Part Of: Journal of cellular and molecular medicine. Volume 26:Issue 22(2022)
• Page Start: 5565
• Page End: 5579
• Publication Date: 2022-11-01
• Subjects: ferroptosis -- immune -- lipid peroxidation -- therapy -- tumor microenvironment; Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.17529
• Languages: English
• ISSNs: 1582-1838

Abstract

Abstract: Ferroptosis is a type of regulated cell death (RCD), and it plays an important role in the occurrence of diseases, especially the development of tumors. Ferroptosis of tumor cells affects the antitumor immunity and the immune response to treatment to varying degrees. Ferroptosis also plays a key role in immune cells. This review outlines the mechanism of the immune‐related effects of ferroptosis pathways in tumor progression and treatment, and it discusses potential methods for improving antitumor immunity and enhancing the efficacy of current cancer treatments by targeting ferroptosis.