Retracted: Curcumin derivative L6H4 inhibits proliferation and invasion of gastric cancer cell line BGC‐823. Issue 1 (22nd September 2018)

• Record Type: Journal Article
• Authors: Mu, Jianfeng; Wang, Xiaodong; Dong, Lihua; Sun, Pengda
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 1(2019)
• Page Start: 1011
• Page End: 1017
• Publication Date: 2018-09-22
• Subjects: antitumor -- curcumin L6H4 -- gastric cancer; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.27542
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: Curcumin and its chalcone derivatives have well‐known, explicit biological antitumor properties, such as instance antiproliferative and apoptotic effects via multiple molecular targets. In this study, we investigated the anticancer activity of curcumin derivative L6H4 (curcumin L6H4) on gastric cancer cells. Inhibitory effects of curcumin L6H4 on gastric cancer cells (BGC‐823) were studied by the diphenyltetrazolium (MTT) assay, and cell apoptosis was detected by Annexin‐V/propidium iodide (PI) staining and then analyzed by flow cytometry. A mouse xenotransplant gastric tumor model was established to detect the role of curcumin L6H4 in vivo. The apoptosis‐related proteins p53, p21, Bax, and Bcl‐2 in BGC‐823 cells and mouse xenotransplant models treated with curcumin L6H4 were determined by Western blot analysis. Curcumin L6H4 can significantly inhibit the proliferation and induce the apoptosis of BGC‐823 cells, thus enhancing the expression levels of p53, p21, Bax, and Bcl‐2 noticeably in vivo and in vitro. Meanwhile, curcumin L6H4 can remarkably suppress the growth of tumor cells in animal models. These results suggest that curcumin derivative L6H4 has potent of antitumor properties in vitro or in vivo.