The role of heat shock proteins in metastatic colorectal cancer: A review. Issue 11 (5th September 2022)

• Record Type: Journal Article
• Authors: Javid, Hossein; Hashemian, Pedram; Yazdani, Shaghayegh; Sharbaf Mashhad, Alireza; Karimi‐Shahri, Mehdi
• Is Part Of: Journal of cellular biochemistry. Volume 123:Issue 11(2022)
• Page Start: 1704
• Page End: 1735
• Publication Date: 2022-09-05
• Subjects: colorectal cancer (CRC) -- heat shock proteins (HSPs) -- metastatic colorectal cancer; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.30326
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: Heat shock proteins (HSPs) are a large molecular chaperone family classified by their molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs are likely to have antiapoptotic properties and participate actively in various processes such as tumor cell proliferation, invasion, metastases, and death. In this review, we discuss comprehensively the functions of HSPs associated with the progression of colorectal cancer (CRC) and metastasis and resistance to cancer therapy. Taken together, HSPs have numerous clinical applications as biomarkers for cancer diagnosis and prognosis and potential therapeutic targets for CRC and its related metastases.