Thirteen cancers associated with HIV infection in a Black South African cancer patient population (1995‐2016). Issue 2 (2nd September 2022)

• Record Type: Journal Article
• Authors: Sengayi‐Muchengeti, Mazvita; Singh, Elvira; Chen, Wenlong Carl; Bradshaw, Debbie; de Villiers, Chantal Babb; Newton, Robert; Waterboer, Tim; Mathew, Christopher G; Sitas, Freddy
• Is Part Of: International journal of cancer. Volume 152:Issue 2(2023)
• Page Start: 183
• Page End: 194
• Publication Date: 2022-09-02
• Subjects: Africa -- anti‐retroviral treatment -- HIV associated cancers; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.34236
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract: South Africa's HIV epidemic has evolved over time in terms of numbers of people living with HIV, access to antiretroviral treatment (ART) and age. These changes have profoundly influenced local cancer patterns. The Johannesburg Cancer Study has, over a period of 22 years (1995‐2016), recruited over 20 000 incident black cancer patients who consented to provide answers to a questionnaire and blood samples (serum, DNA). This has presented a unique opportunity to examine the evolving association of HIV with cancer in Africa. We used logistic regression models to explore case‐control associations between specific cancers and HIV, using participants with non‐infection related cancers as controls. Using data of 20 835 cancer patients with confirmed HIV status, we found the following cancers to be associated with HIV: Kaposi's sarcoma (ORadj ; 95%CI): (99.1;72.6‐135.1), non‐Hodgkin lymphoma (11.3;9.3‐13.6), cervical cancer (2.7;2.4‐3.0), Hodgkin lymphoma (3.1;2.4‐4.2), cancer of the eye/conjunctiva (18.7;10.1‐34.7), anogenital cancers (anus [2.1;1.4‐3.2], penis [5.4;2.7‐10.5], vulva [4.8;3.5‐6.4], vagina [5.5;3.0‐10.2]), oropharyngeal cancer (1.6;1.3‐1.9), squamous cell carcinoma of the skin (3.5;2.4‐4.9), melanoma (2.0;1.2‐3.5) and cancer of the larynx (1.7;1.3‐2.4). Kaposi's sarcoma odds ratios increased from the pre‐ART (1995‐2004) to the early ART (2005‐2009) period but declined in the late ART (2010‐2016) period. Odds ratios for cancers of the eye/conjunctiva, cervix, penis and vulva continued to increase in recent ART periods. Our study confirms the spectrum of HIV‐associated cancers found in other African settings. The odds ratios of conjunctival and HPV‐related cancers continue to rise in the ART era as the HIV positive population ages. Abstract : What's new? In South Africa, the changing shape of the HIV epidemic has also shifted patterns of cancer. Here, the authors studied the association between HIV infection and cancer incidence over a 22‐year period. More than 20, 000 black cancer patients participated, contributing information about HIV infection status, lifestyle and behavior, and other risk factors. The researchers found that 13 cancers were associated with HIV infection. As antiretroviral treatments become more available and the population living with HIV ages, odds ratios of HPV‐related cancers and conjunctival cancer have risen, suggesting a need for education and surveillance among people living with HIV.