Front Cover Picture: Zincate‐Mediated Remote Functionalisation of p‐Iodobenzyl Derivatives Through Metallotropy in 2‐Methyltetrahydrofuran as Key Solvent (Adv. Synth. Catal. 22/2022). Issue 22 (21st October 2022)

• Record Type: Journal Article
• Authors: Pierret, Alexandre; Denhez, Clément; Gros, Philippe C.; Vasseur, Alexandre
• Is Part Of: Advanced synthesis & catalysis. Volume 364:Issue 22(2022)
• Page Start: 3755
• Page End: 3755
• Publication Date: 2022-10-21
• Subjects: Zincate -- Green solvent -- Remote functionalisation -- metallotropy -- metal-shift; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202201101
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract : The front cover picture illustrates the 1, 5‐rearrangement of lithium benzyl(dibutyl)zincate derived from p ‐iodobenzyl mesylate. This key elementary step is integral to a complex reaction sequence allowing the remote functionalisation of such a derivative with a wide range of aldehydes (see fruits in the tree). As a remote leaving group (here OMs) is required to trigger the chemical event, the release of LiOMs can be seen as a driving force (LiOMs is thus the driver of the boat). Details can be found in the Research Article by Alexandre Vasseur and co‐workers (A. Pierret, C. Denhez, P. C. Gros, A. Vasseur, Adv. Synth. Catal . 2022, 364, 3805–3816; DOI: 10.1002/adsc.202200475 ).