Nitrothiazole‐Thiazolidinone Hybrids: Synthesis and in Vitro Antimicrobial Evaluation. Issue 11 (6th October 2022)

• Record Type: Journal Article
• Authors: Hart, Dylan; Legoabe, Lesetja J.; Jesumoroti, Omobolanle J.; Jordaan, Audrey; Warner, Digby F.; Steventon, Rebecca; Beteck, Richard M.
• Is Part Of: Chemistry & biodiversity. Volume 19:Issue 11(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-06
• Subjects: antimicrobial -- 5-nitrothiazoles -- thiazolidine-4-ones -- molecular hybridization -- ESKAPE pathogens; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202200729
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Herein we report the synthesis of novel compounds inspired by the antimicrobial activities of nitroazole and thiazolidin‐4‐one based compounds reported in the literature. Target compounds were investigated in vitro for antitubercular, antibacterial, antifungal, and overt cell toxicity properties. All compounds exhibited potent antitubercular activity. Most compounds exhibited low micromolar activity against S. aureus and C. albicans with no overt cell toxicity against HEK‐293 cells nor haemolysis against human red blood cells. Notably, compound 3b exhibited low to sub‐micromolar activities against Mtb, MRSA, and C. albicans . 3b showed superior activity (0.25 μg/ml) against MRSA compared to vancomycin (1 μg/ml). Abstract :