Robust estimation of 1/f activity improves oscillatory burst detection. (11th October 2022)

• Record Type: Journal Article
• Authors: Seymour, Robert A.; Alexander, Nicholas; Maguire, Eleanor A.
• Is Part Of: European journal of neuroscience. Volume 56:Number 10(2022)
• Page Start: 5836
• Page End: 5852
• Publication Date: 2022-10-11
• Subjects: 1/f -- burst detection -- neurophysiology -- oscillations -- signal processing -- theta; Nervous system -- Periodicals; 612.8
• DOI: 10.1111/ejn.15829
• Languages: English
• ISSNs: 0953-816X

Abstract

Abstract: Neural oscillations often occur as transient bursts with variable amplitude and frequency dynamics. Quantifying these effects is important for understanding brain–behaviour relationships, especially in continuous datasets. To robustly measure bursts, rhythmical periods of oscillatory activity must be separated from arrhythmical background 1/f activity, which is ubiquitous in electrophysiological recordings. The Better OSCillation (BOSC) framework achieves this by defining a power threshold above the estimated background 1/f activity, combined with a duration threshold. Here we introduce a modification to this approach called fBOSC, which uses a spectral parametrisation tool to accurately model background 1/f activity in neural data. fBOSC (which is openly available as a MATLAB toolbox) is robust to power spectra with oscillatory peaks and can also model non‐linear spectra. Through a series of simulations, we show that fBOSC more accurately models the 1/f power spectrum compared with existing methods. fBOSC was especially beneficial where power spectra contained a 'knee' below ~.5–10 Hz, which is typical in neural data. We also found that, unlike other methods, fBOSC was unaffected by oscillatory peaks in the neural power spectrum. Moreover, by robustly modelling background 1/f activity, the sensitivity for detecting oscillatory bursts was standardised across frequencies (e.g., theta‐ and alpha‐bands). Finally, using openly available resting state magnetoencephalography and intracranial electrophysiology datasets, we demonstrate the application of fBOSC for oscillatory burst detection in the theta‐band. These simulations and empirical analyses highlight the value of fBOSC in detecting oscillatory bursts, including in datasets that are long and continuous with no distinct experimental trials. Abstract : To determine a power threshold for burst detection, the Better OSCillation framework (BOSC) estimates background 1/f activity by modelling neural power spectra. Here we introduce a modification, termed fBOSC, to more robustly estimate 1/f activity in situations with prominent oscillatory peaks and/or the presence of a non‐linear 'knee' in the power spectrum. This was shown to standardise burst detection across frequency bands in both simulated and empirical data.