Self‐driven Electrical Stimulation Promotes Cancer Catalytic Therapy Based on Fully Conjugated Covalent Organic Framework Nanocages. (18th September 2022)

• Record Type: Journal Article
• Authors: Yao, Shuncheng; Zheng, Minjia; Wang, Shaobo; Huang, Tian; Wang, Zhuo; Zhao, Yunchao; Yuan, Wei; Li, Zhou; Wang, Zhong Lin; Li, Linlin
• Is Part Of: Advanced functional materials. Volume 32:Number 47(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-18
• Subjects: cancer therapies -- electron mobilities -- nanocages -- nanozymes -- self‐driven electrical stimulations; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202209142
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Engineered nanozymes have been developed to catalyze the production of reactive oxygen species (ROS) for cancer therapy, but currently, the ROS generation efficiency is still far from optimistic. In this study, a human self‐driven electrical stimulation enhanced catalytic system based on wearable triboelectric nanogenerator (TENG) and fully π‐conjugated covalent organic framework nanocages (hCOF) for improving cancer therapy is created. The fully π‐conjugated hCOF nanocage with high electron mobility under the self‐generated electric field can not only rearrange the local electric field for optimizing energy utilization, but also facilitates the access of electrolytes to optimize the utilization of the electric field. With the self‐powered wearable TENG, the peroxidase‐like activity of hCOF increased by 2.44‐fold and has electricity‐responsive doxorubicin delivery capacity for enhancing the therapeutic outcomes. The high‐efficient self‐driven electrical stimulation enhanced nanocatalytic system provides a new optimized model for the catalytic energy supply of nanozymes. Abstract : Self‐driven electrical stimulation is imposed on fully conjugated covalent organic framework nanocages (hCOF) with high electron mobility to rearrange the local electric field and optimize energy utilization, therefore improving cancer catalytic therapy. With the self‐powered triboelectric nanogenerator, the peroxidase‐like activity of hCOF increased by 2.44‐fold for enhancing the cancer therapeutic outcomes.