A 90‐channel triaxial magnetoencephalography system using optically pumped magnetometers. Issue 1 (5th September 2022)

• Record Type: Journal Article
• Authors: Rea, Molly; Boto, Elena; Holmes, Niall; Hill, Ryan; Osborne, James; Rhodes, Natalie; Leggett, James; Rier, Lukas; Bowtell, Richard; Shah, Vishal; Brookes, Matthew J.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1517:Issue 1(2022)
• Page Start: 107
• Page End: 124
• Publication Date: 2022-09-05
• Subjects: electrophysiology -- human brain imaging -- magnetoencephalography -- optically pumped magnetometers; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.14890
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract: Magnetoencephalography (MEG) measures the small magnetic fields generated by current flow in neural networks, providing a noninvasive metric of brain function. MEG is well established as a powerful neuroscientific and clinical tool. However, current instrumentation is hampered by cumbersome cryogenic field‐sensing technologies. In contrast, MEG using optically pumped magnetometers (OPM‐MEG) employs small, lightweight, noncryogenic sensors that provide data with higher sensitivity and spatial resolution, a natural scanning environment (including participant movement), and adaptability to any age. However, OPM‐MEG is new and the optimum way to design a system is unknown. Here, we construct a novel, 90‐channel triaxial OPM‐MEG system and use it to map motor function during a naturalistic handwriting task. Results show that high‐precision magnetic field control reduced background fields to ∼200 pT, enabling free participant movement. Our triaxial array offered twice the total measured signal and better interference rejection compared to a conventional (single‐axis) design. We mapped neural oscillatory activity to the sensorimotor network, demonstrating significant differences in motor network activity and connectivity for left‐handed versus right‐handed handwriting. Repeatability across scans showed that we can map electrophysiological activity with an accuracy ∼4 mm. Overall, our study introduces a novel triaxial OPM‐MEG design and confirms its potential for high‐performance functional neuroimaging. Abstract : Magnetoencephalography (MEG) measures the tiny magnetic fields generated by current flow in the brain, but conventional MEG is hampered by cumbersome cryogenic field‐sensing technologies. Our wearable, 90‐channel triaxial optically‐pumped magnetometer (OPM) MEG system—in conjunction with precision magnetic field control that reduced background fields to ∼200 pT—is used here to map electrophysiological activity during handwriting to the motor cortex, with accuracy ∼4 mm.