Rhodium‐Catalyzed Oxidative Coupling of Potassium Vinyltrifluoroborate with Arenes: A Direct Access to Functionalized Styrene Derivatives. Issue 22 (31st October 2022)

• Record Type: Journal Article
• Authors: Ma, Wenbo; Wang, Yang; Li, Bo; Zhou, Yunhao; Xu, Yue; Sun, Yanan; Gu, Linghui; Cheng, An
• Is Part Of: Advanced synthesis & catalysis. Volume 364:Issue 22(2022)
• Page Start: 3881
• Page End: 3887
• Publication Date: 2022-10-31
• Subjects: C−H activation -- Alkenylations -- Potassium Vinyltrifluoroborate -- Styrene derivatives; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202200745
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Herein, we report a Rh(III)‐catalyzed direct alkenylation of arenes with readily available vinyltrifluoroborate to direct access to functionalized styrenes. This method tolerates a wide range of functional groups in 33 examples with excellent site‐ and regioselectivity under mild conditions. The synthetic utility was demonstrated through the further transformation of thus‐obtained functionalized styrenes. Preliminary mechanistic studies indicated that the reaction probably proceeds through an Rh(III)‐catalyzed C−H activation/Suzuki coupling pathway. Abstract :