Synthesis, Spectral Characterization, Antioxidant, Antimicrobial and Anticancer Activities of New Binuclear Copper and Rhodium Complexes. Issue 43 (16th November 2022)

• Record Type: Journal Article
• Authors: Ait‐Ramdane‐Terbouche, Chafia; Elazara, Zakaria Sid; Terbouche, Achour; Lakhdari, Houria; Khalfaoui, Massaab; Boumechhour, Abdenour; Mezaoui, Djillali
• Is Part Of: ChemistrySelect. Volume 7:Issue 43(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-16
• Subjects: Antioxidant and antimicrobial activities -- Binuclear Cu (II) and Rh (III) complexes -- Cytotoxicity assays -- Schiff base -- Stability; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202202937
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Two novel binuclear complexes of Cu (II) and Rh (III) with Bis [4‐hydroxy‐6‐methyl‐3‐{(1E)‐N‐[2‐(ethylamino) ethyl] ethanimidoyl}‐2H‐pyran‐2‐one] (L) were prepared and characterized by elemental analysis, electrospray ionization‐mass spectrometry (ESI‐MS), conductivity, nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT‐IR), ultraviolet‐visible spectrophotometry, fluorescence, thermogravimetric analysis ( TGA), scanning electron microscopy (SEM), energy dispersive X‐ray spectroscopy (EDX) and cyclic voltammetry (CV). The spectral data indicate that the ligand binds the metal ions via the oxygen atom of the phenolic group, the nitrogen atoms of the azomethine and NH groups. These characterizations suggested the formation of binuclear complexes with octahedral geometry around each metal ion. For a better understanding of the response of complexes to biological activities, the stability constants, potential zeta and size of the complexes were determined. From the results, we can deduce that the complexes have more significant activities than their corresponding ligand. Moderate antioxidant activity recorded with both complexes, superior antibacterial and antifungal activities with Rh (III) complex with MIC value of 0.3125 mg. mL −1 and interesting anticancer activity towards Hep2 cells (IC50 =13.77 μM) with Rh (III) and towards Hep2 (IC50 =28.35 μM) and K562 cells (IC50 =26.34 μM) with Cu (II) complex. Abstract : Two binuclear complexes of Cu (II) and Rh (III) with Bis [4‐hydroxy‐6‐methyl‐3‐{(1E)‐N‐[2‐(ethylamino) ethyl] ethanimidoyl}‐2H‐pyran‐2‐one] were prepared and characterized. The stability constants, potential zeta and the biological activities of the complexes were determined. The biological activities showed interesting antibacterial and antifungal activities with Rh (III) complex and significant anticancer activity towards Hep2 cells with Rh (III) complex and towards both cells with Cu (II) complex.