A Lysosome‐Activated Tetrahedral Nanobox for Encapsulated siRNA Delivery (Adv. Mater. 46/2022). Issue 46 (17th November 2022)

• Record Type: Journal Article
• Authors: Gao, Yang; Chen, Xingyu; Tian, Taoran; Zhang, Tao; Gao, Shaojingya; Zhang, Xiaolin; Yao, Yangxue; Lin, Yunfeng; Cai, Xiaoxiao
• Is Part Of: Advanced materials. Volume 34:Issue 46(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-17
• Subjects: DNA nanotechnology -- framework nucleic acids -- lysosome activating -- pH responsiveness -- siRNA delivery; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202270316
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : DNA Nanotechnology Tetrahedral framework nucleic acids have attracted extensive attention as a static drug nanocarrier. In article number 2201731, Xiaxiao Cai and co‐workers report a dynamic lysosome‐activated tetrahedral nanobox for completely encapsulating short interfering RNA. The closed tetrahedral structure endows cargo RNA with active release. This work offers a dynamic pH‐sensitive confinement delivery system for small RNA.