Chemical composition and biological activity of essential oil of Teucrium scordium L. subsp. scordioides (Schreb.) Arcang. (Lamiaceae) from Sardinia Island (Italy). Issue 22 (17th November 2022)

• Record Type: Journal Article
• Authors: Piras, Alessandra; Maccioni, Alfredo; Falconieri, Danilo; Porcedda, Silvia; Gonçalves, Maria José; Alves-Silva, Jorge M.; Silva, Ana; Cruz, Maria Teresa; Salgueiro, Ligia; Maxia, Andrea
• Is Part Of: Natural product research. Volume 36:Issue 22(2022)
• Page Start: 5828
• Page End: 5835
• Publication Date: 2022-11-17
• Subjects: Teucrium scordium L. subsp. scordioides (Schreb.) Arcang. -- essential oil -- antifungal activity -- anti-inflammatory activity -- dermatophytes -- cell migration; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.2018432
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The aim of this study is to demonstrate the antifungal, anti-inflammatory and anti-migratory potential of the essential oil of Teucrium scordium subsp. scordioides (Schreb.) Arcang, a plant widely used in traditional medicine in Sardinia. The oil was rich in germacrene D (25.1%), δ-cadinene (12.9%) and alloaromadendrene (11.3%). The yeast Cryptococcus neoformans and the dermatophytes Trichophyton rubrum, T. mentagrophytes var. interdigitale and Epidermophyton floccosum were the most susceptible fungi to the action of the oil. In lipopolysaccharide (LPS)-stimulated macrophages, the oil was able to decrease nitric oxide production by ca. 30% at 1.25 μL/mL, without affecting cell viability. In the scratch wound assay, it allowed for ca. 36% of wound closure after 18 h, thus showing anti-migratory properties. Overall, this study highlights the potential of this species to mitigate fungal infections associated with an inflammatory response. Furthermore, we also reported for the first time its anti-migratory capacity, thus suggesting anticancer properties. Graphical Abstract: UF0001