Preparation of poly (N-isopropylacrylamide)/polycaprolactone electrospun nanofibres as thermoresponsive drug delivery systems in wound dressing. Issue 3 (11th February 2023)

• Record Type: Journal Article
• Authors: Li, Changgui; Qiu, Yuheng; Li, Rongguo; Li, Mengting; Qin, Ziyu; Yin, Xueqiong
• Is Part Of: International journal of polymeric materials. Volume 72:Issue 3(2023)
• Page Start: 243
• Page End: 251
• Publication Date: 2023-02-11
• Subjects: Poly(N-isopropylacrylamide) -- electrospinning -- thermoresponsive -- drug delivery -- wound dressing; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2021.2006654
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: A thermo-sensitive film composed of polycaprolactone and poly(N-isopropylacrylamide) was fabricated via electrospinning, with ketoconazole as the model drug. The morphology, elemental composition, and surface hydrophilicity of the nanofibres were characterized, and the results showed that nanofibres switched from a hydrophilic to a hydrophobic state as the temperature increased from 25 °C to 37 °C. The drug release profiles of the films suggested that sustained drug release behavior was achieved, and a lower temperature induced a faster delivery. Therefore, the prepared nanofibres could be highly applicable as wound dressings for on-demand and sustained drug release systems based on their temperature-responsive properties. Graphical Abstract: UF0001