Addendum to Dichloromethane [BAT Value Documentation, 2016]. Issue 4 (19th October 2018)

• Record Type: Journal Article
• Authors: Bolt, H.M.; Weistenhöfer, W.; Drexler, H.; Hartwig, A.
• Is Part Of: MAK collection for occupational health and safety. Volume 3:Issue 4(2018)
• Page Start: 2050
• Page End: 2053
• Publication Date: 2018-10-19
• Subjects: dichloromethane -- methylene chloride -- occupational exposure -- biological tolerance value -- BAT value -- EKA -- toxicity; Biological monitoring -- Periodicals; Industrial toxicology -- Periodicals; Hazardous substances -- Periodicals; 615.902
• DOI: 10.1002/3527600418.bb7509e2218
• Languages: English
• ISSNs: 2509-2383

Abstract

Abstract: In 2015 the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated dichloromethane [CAS No. 75‐09‐2 ], considering dichloromethane in blood to characterize the internal exposure. In a chamber study, 14 non‐smokers were exposed to different concentrations of dichloromethane. After exposure to the present MAK value of 50 ml dichloromethane/m³ without physical activity, a concentration of 0.3 mg dichloromethane/l blood was measured. Considering an increased intake due to elevated breathing volume during work, the exposure to 50 ml dichloromethane/m³ results in a blood concentration of 0.5 mg/l. Taking into account this study and the EKA correlation of 2001, a BAT value of 500 µg dichloromethane/l blood was evaluated. Sampling time is straight after exposure.