Addendum zu Tetrachlorethen [BAT Value Documentation in German language, 2018]. Issue 4 (19th October 2018)

• Record Type: Journal Article
• Authors: Bolt, H.M.; Drexler, H.; Hartwig, A.
• Is Part Of: MAK collection for occupational health and safety. Volume 3:Issue 4(2018)
• Page Start: 2092
• Page End: 2097
• Publication Date: 2018-10-19
• Subjects: Tetrachlorethen -- Ethylentetrachlorid -- Per -- Perchlorethylen -- Arbeitsstoff -- biologischer Toleranzwert -- BAT‐Wert -- biologischer Leitwert -- Toxizität; Biological monitoring -- Periodicals; Industrial toxicology -- Periodicals; Hazardous substances -- Periodicals; 615.902
• DOI: 10.1002/3527600418.bb12718d0023
• Languages: English
• ISSNs: 2509-2383

Abstract

Abstract: In 2017, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated tetrachloroethylene [CAS No. 127‐18‐4 ] considering tetrachloroethylene in blood to characterize the internal exposure at the workplace. Available publications are described in detail. The exposure equivalents for carcinogenic substances (EKA) of tetrachloroethylene uptake by inhalation and tetrachloroethylene in blood were confirmed and extended due to recent data. The evaluation of the BAT value was based on the relationship between tetrachloroethylene uptake by inhalation at the MAK value and the corresponding concentration of tetrachloroethylene in blood. An eight‐hour exposure to the present MAK value of 10 ml tetrachloroethylene/m 3 correlates 16 hours after exposure with a mean tetrachloroethylene concentration in blood of approximately 200 µg/l. Therefore, a BAT value of 200 µg tetrachloroethylene/l blood was evaluated. Sampling time is 16 hours after exposure.