Estimation of accelerated failure time due to exposure risk using piecewise-exponential model in cohort follow-up study. Issue 3 (1st February 2021)

• Record Type: Journal Article
• Authors: Nakashima, Eiji
• Is Part Of: Communications in statistics. Volume 50:Issue 3(2021)
• Page Start: 725
• Page End: 737
• Publication Date: 2021-02-01
• Subjects: Accelerated failure time -- ERR model -- grouped Poisson -- piecewise-exponential -- carcinogenesis mechanistic -- atomic bomb survivors; Mathematical statistics -- Periodicals; Mathematics; Statistics; 519.2
• DOI: 10.1080/03610926.2019.1640878
• Languages: English
• ISSNs: 0361-0926

Abstract

Abstract: Piecewise-exponential excess-relative-risk (ERR) model is used for analysis of large cohort follow-up grouped data of exposure risk. Estimation method for the expected-acceleration-time (EAT) to failure by exposure is proposed using the ERR. Method is applied to all solid cancer mortality atomic-bomb survivor grouped data, and gives EAT to death, 9.9 y (95%CI: 8.4, 11.2 y), at 1 Gy during 50 y follow-up (1950–2000). Longevity (all causes of death) is shorter than the reported before. The exposed younger gives greater EAT. The EAT under carcinogenesis mechanistic model with single-point/chronic exposure is mentioned. Competing causes of cancer death may imply the proneness of double cancer.