Microwave-Assisted One-Pot Three Component Synthesis of Some Thiazolyl(Hydrazonoethyl)Thiazoles as Potential Anti-Breast Cancer Agents. (26th November 2022)

• Record Type: Journal Article
• Authors: Mahmoud, Huda K.; Abdelhady, Hyam A.; Elaasser, Mahmoud M.; Hassain, Doaa Z. H.; Gomha, Sobhi M.
• Is Part Of: Polycyclic aromatic compounds. Volume 42:Number 10(2022)
• Page Start: 7232
• Page End: 7246
• Publication Date: 2022-11-26
• Subjects: Microwave irradiation -- hydrazones -- hydrazonoyl halides -- cyclization -- multi-component reactions -- MCF-7; Polycyclic aromatic compounds -- Periodicals; 547
• DOI: 10.1080/10406638.2021.1998146
• Languages: English
• ISSNs: 1040-6638

Abstract

Abstract: In the present work, 1-(4-methyl-2-(2-(1-(thiophen-2-yl)ethylidene)hydrazinyl) thiazol-5-yl)ethanone was used as building block for synthesis of novel four series of 5-(1-(2-(thiazol-2-yl)hydrazono)ethyl) thiazole derivatives in a one-pot three-component reaction using both thermal heating and microwave irradiation for comparison. All the structures of the synthesized compounds were elucidated based on their elemental analyses and spectral measurements. The bioactivities of the synthesized compounds were evaluated their antitumor activities against MCF-7 tumor cells in comparison with vinblastine sulfate and cisplatin reference drugs using MTT assay and the results revealed promising activities of five compounds (4d, 8b, 12e, 4a, and 12d ).