Pyrimidine-Piperazine Hybrids; Recent Synthesis and Biological Activities. (26th November 2022)

• Record Type: Journal Article
• Authors: Al-Ghorbani, Mohammed; Gouda, Moustafa A.; Baashen, Mohammed; Ranganatha V., Lakshmi
• Is Part Of: Polycyclic aromatic compounds. Volume 42:Number 10(2022)
• Page Start: 7187
• Page End: 7216
• Publication Date: 2022-11-26
• Subjects: Pyrimidine -- piperazine -- heterocycles -- synthesis -- biological activity; Polycyclic aromatic compounds -- Periodicals; 547
• DOI: 10.1080/10406638.2021.1998144
• Languages: English
• ISSNs: 1040-6638

Abstract

Abstract: Pyrimidine and piperazine are well known as being the backbone of many bulky compounds and a vital core structure in approved drugs; previous studies have shown that combining a pyridine ring with a piperazine moiety within a single structural framework enhances biological activity. Despite vast resources enriched with a heterocyclic hybrid structure, a few reported studied on the synthesis and biological activities of pyrimidine-piperazine analogs were discussed. In this review, we summarize current design methods for the construction of pyrimidine-piperazine hybrids by coupling substituted piperazine on various positions of a pyrimidine ring and studied their biological studies.