A MnOx-nucleic acid nanoprobe with enzyme-free cascade signal amplification for ultrasensitive intracellular microRNA imaging. Issue 92 (2nd November 2022)

• Record Type: Journal Article
• Authors: Xu, Jiayao; Qin, Yuxin; Liang, Qiuyi; Zhong, Xiaohong; Hou, Li; Huang, Yong; Zhao, Shulin; Liang, Hong
• Is Part Of: Chemical communications. Volume 58:Issue 92(2022)
• Page Start: 12883
• Page End: 12886
• Publication Date: 2022-11-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc03980j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A schematic illustration of a MnO x -nucleic acid nanoprobe for amplified fluorescence detection and imaging of miRNA in living cells based on the combination of catalytic hairpin assembly, hybridization chain reaction, and DNAzyme amplification. Abstract : A novel MnO x -nucleic acid nanoprobe was constructed for catalytic imaging of microRNA in living cells based on the combination of catalytic hairpin assembly, hybridization chain reaction, and DNAzyme amplification. This nanoprobe exhibited ultrahigh sensitivity and specificity, and could distinguish tumor cells and normal cells by live cell microRNA imaging.