Ultra-thin silica shell-guarded nanoflares for high-fidelity live cell miRNA-21 imaging by fully avoiding the interference of biothiols. Issue 23 (11th November 2022)

• Record Type: Journal Article
• Authors: Luo, Yuze; Wang, Zefeng; Li, Junqin; Yi, Wenhua; Yang, Ke; Ou, Chunlei; Deng, Le; He, Dinggeng
• Is Part Of: Analyst. Volume 147:Issue 23(2022)
• Page Start: 5269
• Page End: 5273
• Publication Date: 2022-11-11
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/d2an01441f
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : Ultra-thin silica-guarded nanoflares (Au@SiO2 NFs) are constructed for high-fidelity live cell microRNA imaging by avoiding the interference of intracellular biothiols. Abstract : We successfully constructed a new class of nanoflares based on ultra-thin silica-coated gold nanoparticles (Au@SiO2 ) with the covalent binding of nucleic acids, which demonstrated more resistance to biothiols than that exhibited in the traditional Au–S binding strategy, for imaging the target miRNA-21 with high fidelity in living cells.