Palladium-catalyzed Lewis acid-regulated cascade annulation of alkynes with unactivated alkenes to access diverse α-methylene-γ-lactones. Issue 23 (20th October 2022)

• Record Type: Journal Article
• Authors: Li, Jianxiao; He, Dan; Wang, Bowen; Xiong, Wenfang; Qi, Chaorong; Jiang, Huanfeng
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 23(2022)
• Page Start: 6579
• Page End: 6585
• Publication Date: 2022-10-20
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo01500e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A palladium-catalyzed Lewis acid-regulated cascade annulation of alkynes with unactivated alkenes for the preparation of alkyl substituted α-methylene-γ-lactones with excellent Z / E selectivities was accomplished. Abstract : We report herein a novel and versatile divergent carboesterification of unactivated alkenes enabled by Lewis acids and palladium catalysts for the preparation of alkyl substituted α-methylene-γ-lactones in high yields with excellent Z / E selectivities. Downstream late-stage functionalization of ( Z )-γ-lactones afford various valuable complex molecules, and has potential utility in organic synthesis and pharmaceutical chemistry.