Unexpected triaxial preferences in some all-syn 1, 3, 5-trifluorocyclohexanes. Issue 92 (1st November 2022)

• Record Type: Journal Article
• Authors: Yu, Cihang; Piscelli, Bruno A.; Maharik, Nawaf Al; Cordes, David B.; Slawin, Alexandra M. Z.; Cormanich, Rodrigo A.; O'Hagan, David
• Is Part Of: Chemical communications. Volume 58:Issue 92(2022)
• Page Start: 12855
• Page End: 12858
• Publication Date: 2022-11-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc05058g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Theory and solution NMR indicate that all- syn 1, 3, 5-trifluorocyclohexane adopts the expected tri-equatorial conformation, however in the solid state the more polar triaxial conformation is observed. Abstract : Theory and solution NMR indicate that all- syn 1, 3, 5-trifluorocyclohexane 5 adopts the expected tri-equatorial conformation, however in the solid state the more polar triaxial conformation is observed. This and the favoured conformations of substituted (Me, OMe, NH(CO)Me, NHBoc) derivatives of 5 are investigated to explore triaxial C–F preferences.