Rapid synthesis of spirodienones via electrochemical dearomative spirocyclization in flow. Issue 23 (20th October 2022)

• Record Type: Journal Article
• Authors: Li, Nan; Shi, Zhaojiang; Yuan, Yaofeng; Li, Zhen; Ye, Ke-Yin
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 23(2022)
• Page Start: 6586
• Page End: 6591
• Publication Date: 2022-10-20
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo01392d
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An electrochemical dearomative spirocyclization in flow has been developed, featuring the use of electrons as the clean oxidant in a minimum amount of electrolytes to afford diverse spirodienones in a short reaction time. Abstract : The preparation of biologically relevant spirodienones from arenol derivatives is typically performed in batch using superstoichiometric oxidants. Herein, we have developed an electrochemical dearomative spirocyclization in flow, featuring the use of electrons as the clean oxidant in a minimum amount of electrolytes or even the absence of electrolytes to afford diverse spirodienones in a short reaction time.