MicroRNAs in peripheral artery disease: potential biomarkers and pathophysiological mechanisms. (May 2022)

• Record Type: Journal Article
• Authors: Ring, Andrew; Ismaeel, Ahmed; Wechsler, Marissa; Fletcher, Emma; Papoutsi, Evlampia; Miserlis, Dimitrios; Koutakis, Panagiotis
• Is Part Of: Therapeutic advances in cardiovascular disease. Volume 16(2022)
• Publication Date: 2022-05
• Subjects: angiogenesis -- biomarkers -- critical limb ischemia -- hypoxia -- intermittent claudication -- non-coding RNAs; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Treatment -- Periodicals; Cardiovascular pharmacology -- Periodicals; Cardiovascular Diseases -- diagnosis -- Periodicals; Cardiovascular Diseases -- therapy -- Periodicals; Cardiovascular Agents -- therapeutic use -- Periodicals; Cardiovascular Diseases -- drug therapy -- Periodicals; Cardiovascular System -- drug effects -- Periodicals; Cardiologie; Hart- en vaatziekten; Appareil cardiovasculaire -- Maladies -- Périodiques; Appareil cardiovasculaire -- Maladies -- Traitement -- Périodiques; Pharmacologie cardiovasculaire -- Périodiques; 616.10605
• DOI: 10.1177/17539447221096940
• Languages: English
• ISSNs: 1753-9447

Abstract

Peripheral artery disease (PAD) is a disease of atherosclerosis in the lower extremities. PAD carries a massive burden worldwide, while diagnosis and treatment options are often lacking. One of the key points of research in recent years is the involvement of microRNAs (miRNAs), which are short 20-25 nucleotide single-stranded RNAs that can act as negative regulators of post-transcriptional gene expression. Many of these miRNAs have been discovered to be misregulated in PAD patients, suggesting a potential utility as biomarkers for PAD diagnosis. miRNAs have also been shown to play an important role in many different pathophysiological aspects involved in the initiation and progression of the disease including angiogenesis, hypoxia, inflammation, as well as other cellular functions like cell proliferation and migration. The research on miRNAs in PAD has the potential to lead to a whole new class of diagnostic tools and treatments.