Multiple oral squamous cell carcinoma 6 years after allogeneic stem cell transplantation complicated with chronic graft-versus-host disease: A case report. (August 2022)

• Record Type: Journal Article
• Authors: Katz, Joseph; Saleh, Wafaa; Alharbi, Hamad; Farhadfar, Nosha
• Is Part Of: SAGE open medical case reports. Volume 10(2022)
• Publication Date: 2022-08
• Subjects: Hematopoietic stem cell transplantation -- chronic graft-versus-host disease -- oral squamous cell carcinoma; Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1177/2050313X221118203
• Languages: English
• ISSNs: 2050-313X

Abstract

Oral squamous cell carcinoma is a potential long-term complication after hematopoietic stem cell transplantation. This may be related to mechanisms including radiation and chemotherapy regimens, chronic graft-versus-host disease, inflammation, and prolonged immunosuppression. The current case describes the development of multiple oral white thick keratotic lesions in the floor of the mouth and the tongue 6 years after hematopoietic stem cell transplantation complicated with chronic graft-versus-host disease. A biopsy performed with histopathological analysis revealed a well-differentiated squamous cell carcinoma. The patient was treated by subtotal glossectomy, bilateral neck dissection, and flap reconstruction. This report highlights the significance of the routine oral examination of long-term surveillance post hematopoietic stem cell transplantation to ensure early detection of these tumors at potentially treatable stage.