Paraneoplastic Conjunctival Acanthosis Nigricans: A Case Report. Issue 3 (24th March 2021)

• Record Type: Journal Article
• Authors: Huang, Natalie; Yin, Han Y.; Swan, Robert
• Is Part Of: Cornea. Volume 40:Issue 3(2021)
• Page Start: 377
• Page End: 379
• Publication Date: 2021-03-24
• Subjects: paraneoplastic conjunctival acanthosis nigricans -- conjunctival papillomatous growth -- ocular surface disease -- paraneoplastic ocular disease; Cornea -- Periodicals; Cornea -- Periodicals; Cornée -- Périodiques; 617.719
• DOI: 10.1097/ICO.0000000000002513
• Languages: English
• ISSNs: 0277-3740

Abstract

Abstract : Purpose: To report a patient who presented with red eye and diffuse palpebral conjunctival thickening and papillary growth bilaterally. Methods: A 63-year-old woman with a medical history of stage IV adenocarcinoma of the lung with metastasis to the bone, the lung, and the lymph nodes presented with redness and irritation of both eyes for 3 months. The patient has been treated with topical corticosteroids for 3 weeks with no relief of symptoms. Results: Clinical examination and pathology report of conjunctival biopsy confirmed the diagnosis of conjunctival acanthosis nigricans. Conclusions: Conjunctival acanthosis nigricans is a rare paraneoplastic condition that resembles papilloma and can present a challenge in diagnosis. When acanthosis nigricans occurs after the diagnosis of malignancy, it can be an indicator of progression of the underlying condition. The diagnosis of conjunctival acanthosis nigricans in a patient with no history of cancer should prompt clinicians for further malignancy workup.