Connectivity increases during spikes and spike-free periods in self-limited epilepsy with centrotemporal spikes. (December 2022)

• Record Type: Journal Article
• Authors: Goad, Beatrice S.; Lee-Messer, Christopher; He, Zihuai; Porter, Brenda E.; Baumer, Fiona M.
• Is Part Of: Clinical neurophysiology. Volume 144(2022)
• Page Start: 123
• Page End: 134
• Publication Date: 2022-12
• Subjects: Rolandic epilepsy -- Benign Epilepsy with Centrotemporal Spikes (BECTS) -- Childhood Epilepsy with Centrotemporal Spikes (CECTS) -- Connectivity -- Sleep -- Interictal epileptiform discharges (IEDs); FMRI functional Magnetic Resonance Imaging -- GEE Generalized estimating equations -- ICD International Classification of Disease -- SeLECTS Self-limited Epilepsy with Centrotemporal Spikes -- wPLI weighted Phase Lag Index; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2022.09.015
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Connectivity is globally increased during sleep but not wakefulness in SeLECTS compared to age matched controls. Diffuse connectivity increases during spikes are preceded and followed by focal increases in frontocentral connectivity. Right hemisphere connectivity increases only with right spikes; right and left spikes increase left hemisphere connectivity. Abstract: Objective: To understand the impact of interictal spikes on brain connectivity in patients with Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTS). Methods: Electroencephalograms from 56 consecutive SeLECTS patients were segmented into periods with and without spikes. Connectivity between electrodes was calculated using the weighted phase lag index. To determine if there are chronic alterations in connectivity in SeLECTS, we compared spike-free connectivity to connectivity in 65 matched controls. To understand the acute impact of spikes, we compared connectivity immediately before, during, and after spikes versus baseline, spike-free connectivity. We explored whether behavioral state, spike laterality, or antiseizure medications affected connectivity. Results: Children with SeLECTS had markedly higher connectivity than controls during sleep but not wakefulness, with greatest difference in the right hemisphere. During spikes, connectivity increased globally; before and after spikes, left frontal and bicentral connectivity increased. Right hemisphere connectivity increased more during right-sided than left-sided spikes; left hemisphere connectivity was equally affected by right and left spikes. Conclusions: SeLECTS patient have persistent increased connectivity during sleep; connectivity is further elevated during the spike and perispike periods. Significance: Testing whether increased connectivity impacts cognition or seizure susceptibility in SeLECTS and more severe epilepsies could help determine if spikes should be treated.