Cordiosides A and B, two new 19-hydroxy-29-norlanostane glycosides isolated from the flowers of Cordia lutea. (December 2022)

• Record Type: Journal Article
• Authors: Castro Dionicio, Inés Y.; Fabre, Nicolas; Saffon-Merceron, Nathalie; Sauvain, Michel; Castillo, Denis; Jullian, Valérie
• Is Part Of: Phytochemistry letters. Volume 52(2022)
• Page Start: 40
• Page End: 44
• Publication Date: 2022-12
• Subjects: Cordia lutea -- Boraginaceae -- Helicobacter pylori -- Antibacterial -- 19-Hydroxy-29-norlanostane -- Peruvian traditional medicine; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2022.08.015
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: We present here the isolation and structural characterization of two undescribed mono-glycosylated triterpenes with a 19-hydroxy-29-norlanostane core. These compounds (1 -2 ) were isolated from an ethanolic extract of the dried flowers of Cordia lutea, a widely used Peruvian traditional medicine. Their structures were determined by examination of their NMR and MS data. For compound 1, its structure was confirmed by single crystal X-ray structural analyses. 1 showed moderate activity against Helicobacter pylori (MIC = 15.6 µg/mL), and was not active against Escherichia coli, Pseudomonas aeruginosa or Staphylococcus aureus (MIC > 125 µg/mL). Graphical Abstract: ga1 Highlights: Cordia lutea is a widely used as a medicinal plant in Peru. Little is known about its chemical composition. Two new 19-hydroxy-29-norlanostane triterpenes were isolated from this herbal remedy. One compound displayed moderate activity against Helicobacter pylori, supporting the traditional use of this plant.