How to kill an ERKsome target: PROTACs deliver the deathblow. Issue 11 (17th November 2022)

• Record Type: Journal Article
• Authors: Potts, Malia B.
• Is Part Of: Cell chemical biology. Volume 29:Issue 11(2022)
• Page Start: 1569
• Page End: 1571
• Publication Date: 2022-11-17
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2022.11.002
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : In this issue of Cell Chemical Biology, You et al. demonstrate that selective degradation of ERK5 exhibits neither anti-proliferative nor anti-inflammatory activities previously attributed to ERK5 inactivation. This settles a longstanding debate in the field and highlights the power of PROTACs to investigate non-enzymatic activities of target proteins. Abstract : In this issue of Cell Chemical Biology, You et al. demonstrate that selective degradation of ERK5 exhibits neither anti-proliferative nor anti-inflammatory activities previously attributed to ERK5 inactivation. This settles a longstanding debate in the field and highlights the power of PROTACs to investigate non-enzymatic activities of target proteins.